Abstract |
There is a growing interest in the auditory community to develop novel prophylactic and therapeutic drugs to prevent permanent sensorineural hearing loss following acute cochlear injury. The jun-N-terminal protein kinase (JNK) pathway plays a crucial role in acute sensory hearing loss. Blocking the JNK pathway using the cell-penetrating peptide D-JNKI-1 ( AM-111/brimapitide) has shown promise as both a prophylactic and therapeutic agent for acute cochlear injury. A number of pre-clinical and clinical studies have determined the impact of D-JNKI-1 on acute sensorineural hearing loss. Given the inner-ear selective therapeutic profile, local route of administration, and ability to diffuse across cellular membranes rapidly using both active and passive transport makes D-JNK-1 a promising oto- protective drug. In this review article, we discuss the application of D-JNKI-1 in various auditory disorders as well as its pharmacological properties and distribution in the cochlea.
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Authors | Adrien A Eshraghi, Mayank Aranke, Richard Salvi, Dalian Ding, John K M Coleman Jr, Emre Ocak, Rahul Mittal, Thomas Meyer |
Journal | Hearing research
(Hear Res)
Vol. 368
Pg. 86-91
(10 2018)
ISSN: 1878-5891 [Electronic] Netherlands |
PMID | 29573879
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2018 Elsevier B.V. All rights reserved. |
Chemical References |
- Cell-Penetrating Peptides
- Enzyme Inhibitors
- Peptides
- JNK Mitogen-Activated Protein Kinases
- D-JNKI-1
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Topics |
- Animals
- Cell Membrane Permeability
- Cell-Penetrating Peptides
(administration & dosage)
- Cochlea
(drug effects, enzymology, injuries, physiopathology)
- Cochlear Diseases
(complications, drug therapy, enzymology, physiopathology)
- Cytoprotection
- Enzyme Inhibitors
(administration & dosage)
- Hearing
(drug effects)
- Hearing Loss, Sensorineural
(enzymology, etiology, physiopathology, prevention & control)
- Humans
- JNK Mitogen-Activated Protein Kinases
(antagonists & inhibitors, metabolism)
- Peptides
(administration & dosage)
- Prognosis
- Risk Factors
- Signal Transduction
(drug effects)
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