Prospective monitoring of adenovirus infection and type analysis after allogeneic hematopoietic cell transplantation: A single-center study in Korea.

Abstract

BACKGROUND:

Epidemiologic studies of human adenovirus (HAdV) in allogeneic hematopoietic cell transplantation (HCT) recipients have been conducted mostly in European countries where HAdV 2 (species C) has been most prevalent in the community. The main objective of this study was to investigate the epidemiology and the characteristics of HAdV infection in Korean allogeneic HCT recipients (<19 years).

METHODS:

In a prospective study from April 2012 to September 2015, HAdV in blood, urine, and stool specimens were monitored weekly from transplantation to day 100 or after if clinically suspected. HAdV infection was defined as positive HAdV PCR result in any specimens regardless of symptoms.

RESULTS:

A total of 1734 specimens were collected from 57 consecutively enrolled recipients. The cumulative incidence of HAdV infection at day 100, and 1 year was 10%, and 20%, and the incidence of viremia was 2% and 6%, respectively. The median onset time from HCT to viremia was 221 days (range, 7-596 days). All viremia cases were caused by only HAdV 3 (species B), whereas several types were detected in stool. Among patients with HAdV infection, lower absolute lymphocyte counts and extensive chronic graft-vs-host disease were associated with viremia (P = .028 and P = .006, respectively).

CONCLUSIONS:

Compared to western studies, this study demonstrated a lower incidence and delayed onset of HAdV infections and HAdV 3 was most prevalent in Korea.

• Authors: Ji-Man Kang, Ki-Sup Park, Jong Min Kim, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Keon Hee Yoo, Ki Woong Sung, Hong-Hoe Koo, Yae-Jean Kim
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 20 Issue 3 Pg. e12885 (Jun 2018) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 29569813 (Publication Type: Journal Article)
• Copyright: © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• DNA, Viral

Topics

• Adenovirus Infections, Human (blood, epidemiology, urine, virology)
• Adenoviruses, Human (classification, isolation & purification)
• Adolescent
• Child
• Child, Preschool
• DNA, Viral (blood)
• Feces (virology)
• Female
• Graft vs Host Disease
• Hematopoietic Stem Cell Transplantation (adverse effects, statistics & numerical data)
• Humans
• Incidence
• Infant
• Lymphocyte Count
• Male
• Prospective Studies
• Republic of Korea (epidemiology)
• Transplantation, Homologous (adverse effects, statistics & numerical data)
• Viral Load
• Viremia