Apolipoprotein E genotypes and longevity across dementia disorders.

Abstract

INTRODUCTION:

The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied.

METHODS:

We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity.

RESULTS:

The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P = .006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P = .028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders.

DISCUSSION:

The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.

• Authors: Tobias Skillbäck, Ronald Lautner, Niklas Mattsson, Jonathan M Schott, Ingmar Skoog, Katarina Nägga, Lena Kilander, Anders Wimo, Bengt Winblad, Maria Eriksdotter, Kaj Blennow, Henrik Zetterberg
• Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association (Alzheimers Dement) Vol. 14 Issue 7 Pg. 895-901 (07 2018) ISSN: 1552-5279 [Electronic] United States
• PMID: 29548722 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Apolipoproteins E

Topics

• Aged
• Alleles
• Alzheimer Disease (genetics)
• Apolipoproteins E (genetics)
• Dementia, Vascular (genetics)
• Female
• Gene Frequency
• Genotype
• Humans
• Longevity (genetics)
• Male
• Middle Aged
• Risk Factors