Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats.

Abstract

The activity of the newly synthesized ruthenium derivative imidazolium-bis(imidazole)tetrachlororuthenate (III) [ImH(RuIm2Cl4)] was compared with that of 5'-deoxy-5-fluorouridine (5'dFUR) in autochthonous acetoxy-methyl-methylnitrosamine (AMMN)-induced colorectal cancer in SD rats. Following coloscopic diagnosis of colorectal tumors treatment was administered twice weekly for a 10-week period. ImH(RuIm2Cl4) exhibited considerable antitumoral efficacy compared with 5'dFUR (20 T/C % and 60 T/C %, respectively) against the growth of AMMN-induced colorectal adenocarcinoma in SD rats. The mortality rates with ImH(RuIm2Cl4) were dose-related, but its efficacy did not vary in all doses administered.

• Authors: F T Garzon, M R Berger, B K Keppler, D Schmähl
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 19 Issue 4 Pg. 347-9 ( 1987) ISSN: 0344-5704 [Print] Germany
• PMID: 2954714 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Imidazoles
• Organometallic Compounds
• Floxuridine
• imidazolium-bis(imidazole)tetrachlororuthenate(III)
• methyl(acetoxymethyl)nitrosamine
• Ruthenium
• Dimethylnitrosamine
• doxifluridine

Topics

• Adenocarcinoma (chemically induced, drug therapy)
• Animals
• Colonic Neoplasms (chemically induced, drug therapy)
• Dimethylnitrosamine (analogs & derivatives)
• Floxuridine (therapeutic use)
• Imidazoles (therapeutic use)
• Male
• Organometallic Compounds
• Rats
• Rats, Inbred Strains
• Rectal Neoplasms (chemically induced, drug therapy)
• Ruthenium (therapeutic use)