Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility.

Abstract

Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold (collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF.

• Authors: Lijun Ding, Guijun Yan, Bin Wang, Lu Xu, Yan Gu, Tong Ru, Xiaoying Cui, Lei Lei, Jingyu Liu, Xiaoqiang Sheng, Bin Wang, Chunxue Zhang, Yanjun Yang, Ruiwei Jiang, Jianjun Zhou, Na Kong, Feifei Lu, Huaijun Zhou, Yannan Zhao, Bing Chen, Yali Hu, Jianwu Dai, Haixiang Sun
• Journal: Science China. Life sciences (Sci China Life Sci) Vol. 61 Issue 12 Pg. 1554-1565 (12 2018) ISSN: 1869-1889 [Electronic] China
• PMID: 29546669 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Forkhead Box Protein O1
• Forkhead Box Protein O3
• FoxO3 protein, mouse
• Foxo1 protein, mouse
• Estradiol
• Collagen

Topics

• Adult
• Animals
• Collagen (chemistry)
• Disease Models, Animal
• Estradiol (blood, metabolism)
• Female
• Forkhead Box Protein O1 (metabolism)
• Forkhead Box Protein O3 (metabolism)
• Humans
• Infertility, Female (therapy)
• Mesenchymal Stem Cell Transplantation
• Mice
• Ovarian Follicle (growth & development, metabolism)
• Phosphorylation
• Pregnancy
• Primary Ovarian Insufficiency (therapy)
• Tissue Scaffolds (chemistry)
• Treatment Outcome
• Wharton Jelly (cytology)