Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: Efficacy of immunoglobulin replacement.

Abstract

Immunoglobulin (Ig) G2 subclass deficiency is known to be associated with recurrent bacterial respiratory infections caused by capsulated bacteria. We encountered a case of recurrent pneumonia due to Streptococcus pneumoniae after allogeneic hematopoietic stem cell transplantation (HSCT). IgG2 subclass level was specifically low, and prophylactic Ig replacement successfully prevented subsequent infections. However, the cessation of Ig replacement resulted in subsequent pneumonia. These findings suggested that IgG2 deficiency could be a cause of recurrent pneumococcal infection after allogeneic HSCT.

• Authors: Rie Yamazaki, Taku Kikuchi, Jun Kato, Masatoshi Sakurai, Yuya Koda, Risa Hashida, Yusuke Yamane, Ryohei Abe, Naoki Hasegawa, Shinichiro Okamoto, Takehiko Mori
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 20 Issue 3 Pg. e12863 (Jun 2018) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 29512243 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Antibodies, Bacterial
• Immunoglobulin G

Topics

• Antibodies, Bacterial
• Female
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• IgG Deficiency
• Immunization, Passive
• Immunoglobulin G (immunology, therapeutic use)
• Male
• Middle Aged
• Pneumococcal Infections (immunology)
• Pneumonia, Bacterial (etiology, immunology)
• Recurrence
• Streptococcus pneumoniae (isolation & purification)
• Treatment Outcome