Pancreatic adenocarcinoma protein-protein interaction network analysis.

Abstract

AIM:

Gene assessment of pancreatic adenocarcinoma disease via protein-protein interaction (PPI) Network Analysis.

BACKGROUND:

Diagnosis, especially early detection of pancreatic adenocarcinoma as a lethal disease implies more investigation. PPI Network Analysis is a suitable tool to discover new aspects of molecular mechanism of diseases.

METHODS:

In the present study the related genes to pancreatic adenocarcinoma are studied in the interactome unit and the key genes are highlighted. The significant clusters were introduced by Cluster-ONE application of Cytoscape software 3.4.0. The genes are retrieved from STRING date base and analyzed by Cytoscape software. The crucial genes based on analysis of central parameters were determined and enriched by ClueGO v2.3.5 via gene ontology.

RESULTS:

The number of 24 key genes among 794 initial genes were highlighted as crucial nodes in relationship with pancreatic adenocarcinoma. All of the key genes were organized in a cluster including 216 nodes. The main related pathways and cancer diseases were determined.

CONCLUSION:

It was concluded that the introduced 24 genes are possible biomarker panel of pancreatic adenocarcinoma.

• Authors: Mostafa Rezaei-Tavirani, Sina Rezaei-Tavirani, Nayebali Ahmadi, Nosratollah Naderi, Saeed Abdi
• Journal: Gastroenterology and hepatology from bed to bench (Gastroenterol Hepatol Bed Bench) Vol. 10 Issue Suppl1 Pg. S85-S92 ( 2017) ISSN: 2008-2258 [Print] Iran
• PMID: 29511477 (Publication Type: Journal Article)