Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis.

Abstract

Thyroid cancer (TC) is the most common endocrine malignancy without reliable preventive agent. Resveratrol possesses in vitro anti-TC activities; while its effect(s) on thyroid tumorigenesis remains unknown. This study aims to address this issue using DEN/MNU/DHPN-induced rat carcinogenesis model. 50 male Sprague-Dawley rats were separated into four groups as Group-1 (5 rats); normally fed; Group-2 (15 rats); DEN/MNU/DHPN treatment only; Group-3 (15 rats) and -4 (15 rats); DEN/MNU/DHPN treatment; followed by resveratrol intragastric (IG) injection and intraperitoneal (IP) injection; respectively; in two-day intervals for 30 weeks. The results revealed that the average resveratrol concentration in thyroid tissues was 1.278 ± 0.419 nmol/g in IG group and 1.752 ± 0.398 nmol/g in IP group. The final body weights of Group-3 and Group-4 were lighter than that (p > 0.05) of Group-1; but heavier than Group-2 (p < 0.05). TC-related lesions (hyperplasia and adenomas) were found in 53.3% of Group-2; 33.3% Group-3 and 26.7% Group-4. Lower serum carcino-embryonic antigen (CEA) and thyroglobulin (Tg) levels; down-regulated expression of IL-6 and cyclooxygenase-2 (COX-2); reduction of NF-κB/p65 nuclear translocation; and elevated IkBα expression were found in the thyroid tissues of Group-3 and Group-4 in comparison with that of Group-2. These results demonstrate that IG and IP administered resveratrol efficiently reduces the frequency and severity of DEN/MNU/DHPN-caused TC-related lesions and would be of values in thyroid tumor prevention.

• Authors: Xu Zheng, Bin Jia, Xue Song, Qing-You Kong, Mo-Li Wu, Ze-Wen Qiu, Hong Li, Jia Liu
• Journal: Nutrients (Nutrients) Vol. 10 Issue 3 (Feb 28 2018) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 29495605 (Publication Type: Journal Article)

Chemical References

• Anticarcinogenic Agents
• Carcinoembryonic Antigen
• Interleukin-6
• Nfkbia protein, rat
• Nitrosamines
• Rela protein, rat
• Stilbenes
• Transcription Factor RelA
• NF-KappaB Inhibitor alpha
• Diethylnitrosamine
• diisopropanolnitrosamine
• Methylnitrosourea
• Thyroglobulin
• Cyclooxygenase 2
• Ptgs2 protein, rat
• Resveratrol

Topics

• Adenoma (blood, chemically induced, pathology, prevention & control)
• Animals
• Anticarcinogenic Agents (pharmacology)
• Carcinoembryonic Antigen (blood)
• Cell Line, Tumor
• Cell Transformation, Neoplastic (chemically induced, drug effects, metabolism, pathology)
• Cyclooxygenase 2 (metabolism)
• Diethylnitrosamine
• Humans
• Hyperplasia
• Interleukin-6 (metabolism)
• Male
• Methylnitrosourea
• NF-KappaB Inhibitor alpha (metabolism)
• Nitrosamines
• Rats, Sprague-Dawley
• Resveratrol
• Stilbenes (pharmacology)
• Thyroglobulin (blood)
• Thyroid Gland (drug effects, metabolism, pathology)
• Thyroid Neoplasms (blood, chemically induced, pathology, prevention & control)
• Time Factors
• Transcription Factor RelA (metabolism)