Abstract | BACKGROUND: METHODS: In this review, we describe the correct acquisition and interpretation of white blood cell scintigraphy and we provide an overview of the existing literature data of the use of this technique in the infected diabetic foot. If images are correctly acquired, displayed and interpreted, this modality reaches very high diagnostic accuracy (>95%) in detecting osteomyelitis and it allows the differential diagnosis with a soft tissue infection or inflammation. Single-photon emission computed tomography/computed tomography (SPECT/CT) in addition to planar images is mandatory to determine the extent and exact location of the infective process in both fore foot and midhint foot. With the addition of bone marrow scintigraphy using radiolabelled nanocolloids, radiolabelled white blood cell scintigraphy is also able to differentiate between Charcot neuroarthropathy and osteomyelitis, which is a challenge in the evaluation of diabetic foot. Radiolabelled anti-granulocyte monoclonal antibodies and their fragments can also be used instead of white blood cells although there is a limited experience on their usefulness in diabetic foot infection.
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Authors | Chiara Lauri, Andor W J M Glaudemans, Alberto Signore |
Journal | Current pharmaceutical design
(Curr Pharm Des)
Vol. 24
Issue 12
Pg. 1270-1276
( 2018)
ISSN: 1873-4286 [Electronic] United Arab Emirates |
PMID | 29484982
(Publication Type: Journal Article, Review)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Organometallic Compounds
- indium oxine
- Technetium Tc 99m Exametazime
- Oxyquinoline
|
Topics |
- Diabetic Foot
(diagnostic imaging)
- Humans
- Leukocytes
(pathology)
- Organometallic Compounds
(chemistry)
- Oxyquinoline
(analogs & derivatives, chemistry)
- Technetium Tc 99m Exametazime
(chemistry)
- Tomography, Emission-Computed, Single-Photon
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