IgE-Selective Immunoadsorption for Severe Atopic Dermatitis.

Abstract

INTRODUCTION:

Recent reports proposed the application of immunoadsorption (IA) for patients with recalcitrant atopic dermatitis (AD) and high-serum IgE levels. However, experience with this novel treatment approach, especially with the newly available IgE-specific adsorber, is limited and recommendation for its use in clinical practice awaits evidence from more studies.

MATERIALS AND METHODS:

Patients with severe AD (SCORAD ≥ 60) and total serum IgE levels ≥750 kU/L were included in this study. The treatment protocol consisted of two cycles of five consecutive treatments with IgE-selective IA 3 weeks apart.

RESULTS:

Ten patients were enrolled and four patients completed the study. The mean SCORAD was significantly improved by up to 43% within a few weeks and until the end of a 6-month follow-up period, with 50% of patients achieving an at least 50% individual reduction of the baseline SCORAD. Each IA cycle induced a temporal average decrement of total serum levels of IgE, IgM, IgA, and IgG by 92, 43, 38, and 35%, respectively. Except for one case of Staphylococcus aureus septicemia, no major adverse events occurred.

CONCLUSION:

Although limited by a considerable withdrawal rate, our observations strengthen our and other recent results further suggesting that IgE-selective IA is an effective treatment option for patients severely affected by AD with highly elevated IgE levels.

• Authors: Michael Kasperkiewicz, Sophie-Charlotte Mook, Diana Knuth-Rehr, Artem Vorobyev, Ralf J Ludwig, Detlef Zillikens, Philip Muck, Enno Schmidt
• Journal: Frontiers in medicine (Front Med (Lausanne)) Vol. 5 Pg. 27 ( 2018) ISSN: 2296-858X [Print] Switzerland
• PMID: 29484297 (Publication Type: Journal Article)