Baicalin is an inhibitor of subgroup J avian leukosis virus infection.

Abstract

Avian leukosis virus subgroup J (ALV-J) can cause great economic losses to the poultry industry worldwide. Baicalin, one of the flavonoids present in S.baicalensis Georgi, has been shown to have antiviral activities. To investigate whether baicalin has antiviral effects on the infection of ALV-J in DF-1 cells, the cells were treated with baicalin at different time points. We found that baicalin could inhibit viral mRNA, protein levels and overall virus infection in a dose- and time-dependent manner using a variety of assays. Baicalin specifically targeted virus internalization and reduced the infectivity of ALV-J particles, but had no effect on the levels of major ALV-J receptor and virus binding to DF-1 cells. Collectively, these results suggest that baicalin might have potential to be developed as a novel antiviral agent for ALV-J infection.

• Authors: Kun Qian, Zheng-Ru Kong, Jie Zhang, Xiao-Wei Cheng, Zong-Yi Wu, Cheng-Xi Gu, Hong-Xia Shao, Ai-Jian Qin
• Journal: Virus research (Virus Res) Vol. 248 Pg. 63-70 (03 15 2018) ISSN: 1872-7492 [Electronic] Netherlands
• PMID: 29481814 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Antiviral Agents
• Flavonoids
• baicalin

Topics

• Animals
• Antiviral Agents (pharmacology)
• Avian Leukosis (drug therapy, virology)
• Avian Leukosis Virus (drug effects, physiology)
• Cell Survival
• Cells, Cultured
• Chickens
• Cytopathogenic Effect, Viral (drug effects)
• Dose-Response Relationship, Drug
• Flavonoids (pharmacology)
• Poultry
• Time Factors
• Virus Attachment (drug effects)
• Virus Internalization (drug effects)
• Virus Replication (drug effects)