Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors.

Abstract

BACKGROUND:

Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors.

MATERIALS AND METHODS:

Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n=30), urinary bladder cancer (n=28), renal cell carcinoma (n=16) and healthy volunteers (control group; n=21).

RESULTS:

In each category, we found a group of amino acids which differed in concentration compared to the control group. These differences were most significant in sarcosine in patients with prostate cancer; leucine, phenylalanine and arginine in those with bladder cancer; and sarcosine, glutamic acid, glycine, tyrosine and arginine in the those with renal cell carcinoma.

CONCLUSION:

Results of our research imply a possible connection between the occurrence of specific types of amino acids in the urine and the presence of urological tumors.

• Authors: Katerina Duskova, Stepan Vesely, Joana DO Carmo Silva, Natalia Cernei, Ondrej Zitka, Zbynek Heger, Vojtech Adam, Klara Havlova, Marek Babjuk
• Journal: In vivo (Athens, Greece) (In Vivo) 2018 Mar-Apr Vol. 32 Issue 2 Pg. 425-429 ISSN: 1791-7549 [Electronic] Greece
• PMID: 29475932 (Publication Type: Journal Article)
• Copyright: Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Amino Acids
• Biomarkers, Tumor
• Prostate-Specific Antigen

Topics

• Adult
• Aged
• Aged, 80 and over
• Amino Acids (urine)
• Biomarkers, Tumor
• Chromatography, Ion Exchange
• Diagnosis, Differential
• Female
• Humans
• Kidney Neoplasms (diagnosis, urine)
• Male
• Middle Aged
• Neoplasm Staging
• Prostate-Specific Antigen (urine)
• Prostatic Neoplasms (diagnosis, urine)
• Sensitivity and Specificity
• Urinary Bladder Neoplasms (diagnosis, urine)
• Urologic Neoplasms (diagnosis, urine)