68Ga-DOTATATE PET-CT imaging in carotid body paragangliomas.

Abstract

OBJECTIVE:

The aim of this study was to present our experience in the baseline evaluation of carotid body paragangliomas (CBP) with 68Ga-DOTATATE PET-CT.

METHODS:

Five patients (4F, 1M; age 24-73 years) with CBPs who underwent 68Ga-DOTATATE PET-CT scan before the treatment were evaluated retrospectively. PET-CT images were analyzed visually as well as semiquantitatively, with measurement of maximum standardized uptake value (SUVmax).

RESULTS:

All patients had unilateral CBP lesion, showed intense 68Ga-DOTATATE uptake in PET-CT. Additionally, 68Ga-DOTATATE avid lesions were found in two patients. One of them had focal intense uptake in thyroid gland and frontal cerebrum. The other one had intense uptake in bone and adrenal mass. Four patients were operated for unilateral primary CBP. Last patient was treated with peptide receptor radionuclide therapy (177Lu-DOTATATE) for both metastatic pheochromocytoma and CBP.

CONCLUSIONS:

68Ga-DOTATATE PET-CT is a valuable imaging modality for staging of CBPs, detecting unknown lesions and changing the management of patients. It is also useful in demonstrating expression of SSTRs for PRRT opportunity.

• Authors: Duygu Has Şimşek, Yasemin Şanlı, Serkan Kuyumcu, Bora Başaran, Ayşe Mudun
• Journal: Annals of nuclear medicine (Ann Nucl Med) Vol. 32 Issue 4 Pg. 297-301 (May 2018) ISSN: 1864-6433 [Electronic] Japan
• PMID: 29468487 (Publication Type: Journal Article)

Chemical References

• Organometallic Compounds
• gallium Ga 68 dotatate

Topics

• Adult
• Aged
• Carotid Body Tumor (diagnostic imaging)
• Female
• Humans
• Male
• Middle Aged
• Organometallic Compounds
• Paraganglioma (diagnostic imaging)
• Positron Emission Tomography Computed Tomography
• Retrospective Studies