Abstract | BACKGROUND: METHODS: Our study considered 2 standard ILE-free PN solutions according to neonatal weight. These solutions were prepared in duplicate and stored at 4°C. The following physicochemical parameters were tested: visual alterations, turbidity, pH, osmolarity, and calcium concentration. Sterility was assessed by means of agar blood culture and glucose concentration determination. In addition, we assessed the stability of simulated Y-site admixtures. For each standard ILE-free PN solution, 2 3-in-1 PN admixtures were designed, considering extreme values of fluid requirements (50 and 150 ml/kg/d) and a fat supply of 2 g/kg/24 h. The physicochemical parameters tested were phase separation and fat mean droplet size distribution. RESULTS: No alterations were detected by visual inspection. Calcium concentrations, turbidity, pH, and osmolarity values remained stable in all the determinations. All agar blood cultures were negative and glucose concentration was constant over time. Physical stability of simulated Y-site admixtures was considered acceptable as mean droplet size distribution remained below 500 nm in all the emulsions. CONCLUSION: The 2 tested standard ILE-free PN solutions for neonates are physicochemically stable and sterile for 31 days under refrigeration (4°C). These solutions are also stable in case of Y-site administration with ILE at the conditions tested.
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Authors | Pau Riera, Gemma Garrido-Alejos, Joana Cardenete, Elisenda Moliner, Edgar Zapico-Muñiz, Daniel Cardona, Noe Garin |
Journal | Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
(Nutr Clin Pract)
Vol. 33
Issue 5
Pg. 694-700
(Oct 2018)
ISSN: 1941-2452 [Electronic] United States |
PMID | 29464781
(Publication Type: Evaluation Study, Journal Article)
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Copyright | © 2018 American Society for Parenteral and Enteral Nutrition. |
Chemical References |
- Amino Acids
- Calcium, Dietary
- Dietary Fats
- Fat Emulsions, Intravenous
- Parenteral Nutrition Solutions
- Pharmaceutical Preparations
- Glucose
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Topics |
- Amino Acids
(analysis)
- Bacteria
(growth & development)
- Calcium, Dietary
(analysis)
- Dietary Fats
(analysis)
- Drug Stability
- Fat Emulsions, Intravenous
(chemistry, standards)
- Glucose
(analysis)
- Humans
- Hydrogen-Ion Concentration
- Infant, Newborn
- Osmolar Concentration
- Parenteral Nutrition
(methods, standards)
- Parenteral Nutrition Solutions
(chemistry, standards)
- Pharmaceutical Preparations
- Sterilization
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