Nano-loaded human umbilical cord mesenchymal stem cells as targeted carriers of doxorubicin for breast cancer therapy.

Abstract

The main challenge of anticancer drugs is poor tumor targeting. Now cellular carriers are widely investigated to deliver anticancer agents. As an ideal cellular candidate, human umbilical cord derived mesenchymal stem cells (hUC-MSCs) possess inherent tropism potential to tumor. Here, we constructed hUC-MSCs carrying transferrin-inspired-nanoparticles that contain doxorubicin(hUC-MSCs-Tf-inspired-NPs) to achieve enhanced anti-tumor efficacy and made an evaluation. Results represented that hUC-MSCs-Tf-inspired-NPs not only exhibit the controlled-release property of Tf-inspired-NPs, but also integrate tumor tropism and penetrative abilities of MSCs. The tumor volume of nude mice bearing breast cancer MCF-7 treated with hUC-MSCs-Tf-inspired-NPs, was remarkably reduced compared to those treated with free drug or Tf-inspired-NPs. Thus, Tf-inspired-NPs loaded hUC-MSCs have a potential to deliver anticancer drugs.

• Authors: Shunxiu Cao, Jiamin Guo, Yujing He, Murad Alahdal, Shanshan Tang, Yuekui Zhao, Zhaocong Yang, Huashan Gao, Wenjun Hu, Hulin Jiang, Lianju Qin, Liang Jin
• Journal: Artificial cells, nanomedicine, and biotechnology (Artif Cells Nanomed Biotechnol) Vol. 46 Issue sup1 Pg. 642-652 ( 2018) ISSN: 2169-141X [Electronic] England
• PMID: 29457930 (Publication Type: Journal Article)

Chemical References

• Drug Carriers
• Doxorubicin

Topics

• Animals
• Breast Neoplasms (drug therapy, pathology)
• Doxorubicin (metabolism, pharmacology, therapeutic use)
• Drug Carriers (chemistry, metabolism)
• Drug Liberation
• Female
• Humans
• MCF-7 Cells
• Mesenchymal Stem Cells (chemistry, cytology, metabolism)
• Mice
• Mice, Nude
• Molecular Targeted Therapy
• Nanostructures (chemistry)
• Umbilical Cord (cytology)