Time course and clinical characterization of cisplatin-induced ototoxicity after treatment for nasopharyngeal carcinoma in a South East Asian population.

Abstract

BACKGROUND:

The purpose of this study was to characterize the clinical course of hearing loss in patients with nasopharyngeal carcinoma (NPC) and the clinical factors affecting its severity.

METHODS:

The time course of hearing loss in patients with NPC was assessed using threshold shift from baseline and Common Terminology Criteria for Adverse Events (CTCAE) grade.

RESULTS:

In the chemoradiotherapy (CRT) groups, the threshold shift was significantly higher from 3 months at 4 kHz (P = 2.30 × 10-9 , concurrent CRT only) but not within 2 years posttreatment in the radiotherapy (RT) group. The CRT groups had worse CTCAE grades than the RT group (percentage of latest CTCAE grade ≥1: 64.9% vs 29.0%, respectively). Cumulative cisplatin dose and cochlear RT dose significantly affects threshold shifts, especially at high frequencies.

CONCLUSION:

Although cisplatin led to high frequency hearing impairment from about 3 months posttreatment, RT conferred no significant hearing impairment in the first 2 years.

• Authors: Sze Ling Chan, Li Shia Ng, Xueying Goh, Chor Hiang Siow, Han Lee Goh, Boon Cher Goh, Timothy Cheo, Kwok Seng Loh, Liam R Brunham
• Journal: Head & neck (Head Neck) Vol. 40 Issue 7 Pg. 1425-1433 (07 2018) ISSN: 1097-0347 [Electronic] United States
• PMID: 29451951 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 Wiley Periodicals, Inc.

Chemical References

• Antineoplastic Agents
• Cisplatin

Topics

• Antineoplastic Agents (administration & dosage, adverse effects)
• Audiometry
• Auditory Threshold
• Chemoradiotherapy
• Cisplatin (administration & dosage, adverse effects)
• Female
• Hearing Loss, Sensorineural (chemically induced, diagnosis)
• Humans
• Male
• Middle Aged
• Nasopharyngeal Neoplasms (drug therapy)
• Radiotherapy, Intensity-Modulated
• Severity of Illness Index
• Time Factors