Coffee is a rich source of bioactive compounds that have potential
anticarcinogenic effects. However, it remains unclear whether
coffee drinking is associated with
colorectal cancer. Also, despite different etiological factors involved in gut physiology, few studies have investigated this association by anatomical site of the lesion. To address these issues, this study examined the association between
coffee drinking and
colorectal cancer in a pooled analysis from 8 cohort studies conducted in Japan. Among 320,322 participants followed up for 4,503,274 person-years, 6,711 incident
colorectal cancer cases were identified. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using the random effects model.
Coffee drinking was not materially associated with
colorectal cancer risk in men or women (pooled HR 0.92, 95% CI 0.82-1.03 in men and pooled HR 0.90, 95% CI 0.76-1.07 in women). Analysis by subsite showed a lower risk of
colon cancer among female drinkers of ≥3 cups
coffee/day (pooled HR 0.80, 95% CI 0.64-0.99). There was no such association in men.
Coffee drinking was not associated with risk of
rectal cancer in men or women. Results were virtually the same among never smokers except for an increased risk of
rectal cancer associated with frequent
coffee consumption.
Coffee drinking may be associated with lower risk of
colon cancer in Japanese women.