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Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers.

Abstract
The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide-chlorophyll-based photodynamic therapy (PDT) agents with "sandwich" dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.
AuthorsQian Cai, Yue Fei, Hong-Wei An, Xiao-Xiao Zhao, Yang Ma, Yong Cong, Liming Hu, Li-Li Li, Hao Wang
JournalACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 10 Issue 11 Pg. 9197-9202 (Mar 21 2018) ISSN: 1944-8252 [Electronic] United States
PMID29443494 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Photosensitizing Agents
Topics
  • Anti-Bacterial Agents
  • Intracellular Space
  • Macrophages
  • Photochemotherapy
  • Photosensitizing Agents
  • Prospective Studies
  • Staphylococcal Infections
  • Staphylococcus aureus

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