Alterations of IGF-1, complement C3 and superoxide dismutase in patients with moderate-to-severe obstructive sleep apnea hypopnea syndrome.

Abstract

AIM:

To evaluate various biomarkers of metabolism, immunity and inflammation in obstructive sleep apnea hypopnea syndrome (OSAHS).

MATERIALS & METHODS:

After overnight polysomnography, blood was collected from 292 OSAHS patients or healthy volunteers. Serum content of inflammatory, immune, metabolic biomarkers were investigated. In addition, the effects of 1-month continuous positive airway pressure (CPAP) were studied in moderate/severe OSAHS.

RESULTS:

C3, serum total complement activity, superoxide dismutase, uric acid were significantly higher in moderate/severe OSAHS than that in no/mild OSAHS. In contrast, IGF-1 in moderate/severe OSAHS was lower than it in no/mild OSAHS, which was negative correlated with apnea-hypopnea index. Moreover, CPAP significantly decreased C3, meanwhile elevated IGF-1.

CONCLUSION:

C3, serum total complement activity and superoxide dismutase were higher in moderate/severe OSAHS, while IGF-1 decreased. Elevated C3 and reduced IGF-1 in moderate/severe OSAHS may be reversed by CPAP.

• Authors: Xiao Wang, Yufeng Wang, Zechuan Cai, Xiaoxia Lu, Zhenxing Li, Yun Chen, Guoliang Zu, Taoping Li
• Journal: Biomarkers in medicine (Biomark Med) Vol. 12 Issue 3 Pg. 217-228 (03 2018) ISSN: 1752-0371 [Electronic] England
• PMID: 29441807 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Complement C3
• Insulin-Like Growth Factor I
• Superoxide Dismutase

Topics

• Adult
• Biomarkers (blood)
• Case-Control Studies
• Complement C3 (analysis)
• Female
• Humans
• Insulin-Like Growth Factor I (analysis)
• Male
• Middle Aged
• Polysomnography
• Respiratory Function Tests
• Risk Factors
• Severity of Illness Index
• Sleep Apnea, Obstructive (diagnosis, pathology)
• Superoxide Dismutase (blood)