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HIPPO Stampede in Nerve Sheath Tumors.

Abstract
Current therapies for malignant peripheral nerve sheath tumors (MPNSTs) are ineffective. The study by Wu et al. in this issue of Cancer Cell provides evidence that the HIPPO pathway is overactive in human MPNSTs and that combined modulation of LATS1/2-YAP/TAZ and PDGFR signaling in Schwann cells reduces MPNST growth.
AuthorsM Laura Feltri, Yannick Poitelon
JournalCancer cell (Cancer Cell) Vol. 33 Issue 2 Pg. 160-161 (02 12 2018) ISSN: 1878-3686 [Electronic] United States
PMID29438691 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2018 Elsevier Inc. All rights reserved.
Chemical References
  • Protein Serine-Threonine Kinases
Topics
  • Hippo Signaling Pathway
  • Humans
  • Nerve Sheath Neoplasms
  • Protein Serine-Threonine Kinases
  • Schwann Cells
  • Signal Transduction

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