Abstract | BACKGROUND/AIMS: METHODS: Relevant studies were systematically retrieved from PubMed, Web of Science and the Cochrane Library. The data that were required to complete 2 × 2 contingency tables were obtained from the included studies. Stratified analyses by cancer type, sample size and publication year were performed. RESULTS: Thirteen studies with 2,276 individuals were included in the meta-analysis. The pooled sensitivity and specificity of circRNAs in the diagnosis of digestive system malignancy were 0.72 [95% confidence interval (CI): 0.65-0.77] and 0.77 (95% CI: 0.72-0.81), respectively. The overall positive likelihood ratio was 3.09 (95% CI: 2.64-3.62), and the overall negative likelihood ratio was 0.37 (95% CI: 0.31-0.44). The pooled diagnostic odds ratio was 8.38 (95% CI: 6.86-10.25), and the overall area under the curve was 0.81 (95% CI: 0.77-0.84), indicating good discriminative ability of circRNAs as biomarkers for digestive system malignancy. CONCLUSION:
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Authors | Zhiqiang Chen, Long Zhang, Guoyong Han, Xueliang Zuo, Yao Zhang, Qin Zhu, Jindao Wu, Xuehao Wang |
Journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
(Cell Physiol Biochem)
Vol. 45
Issue 3
Pg. 962-972
( 2018)
ISSN: 1421-9778 [Electronic] Germany |
PMID | 29428945
(Publication Type: Journal Article, Meta-Analysis)
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Copyright | © 2018 The Author(s). Published by S. Karger AG, Basel. |
Chemical References |
- Biomarkers, Tumor
- RNA, Circular
- RNA
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Topics |
- Area Under Curve
- Biomarkers, Tumor
(genetics, metabolism)
- Databases, Factual
- Gastrointestinal Neoplasms
(diagnosis, genetics, metabolism)
- Humans
- Odds Ratio
- RNA
(genetics, metabolism)
- RNA, Circular
- ROC Curve
- Regression Analysis
- Sensitivity and Specificity
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