Abstract | BACKGROUND: METHODS: RESULTS: A surrogate measure of increased pulmonary artery stiffness, elevated pulmonary arterial elastance (P = .012), along with reduced log(pulmonary artery capacitance) (P = .006) were significantly associated with the presence of diabetes mellitus in patients with pulmonary arterial hypertension in a fully adjusted model. Similar associations between pulmonary arterial elastance and capacitance were noted with both fasting blood glucose and glycated hemoglobin. Furthermore, right ventricular wall thickness on echocardiography was greater in pulmonary arterial hypertension patients with diabetes, supporting the link between right ventricular remodeling and diabetes. CONCLUSION:
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Authors | Morgan E Whitaker, Vineet Nair, Shripad Sinari, Parinita A Dherange, Balaji Natarajan, Lindsey Trutter, Evan L Brittain, Anna R Hemnes, Eric D Austin, Kumar Patel, Stephen M Black, Joe G N Garcia, Jason X Yuan Md PhD, Rebecca R Vanderpool, Franz Rischard, Ayako Makino, Edward J Bedrick, Ankit A Desai |
Journal | The American journal of medicine
(Am J Med)
Vol. 131
Issue 6
Pg. 702.e7-702.e13
(06 2018)
ISSN: 1555-7162 [Electronic] United States |
PMID | 29421689
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2018 Elsevier Inc. All rights reserved. |
Topics |
- Diabetes Mellitus
- Female
- Heart Ventricles
(pathology)
- Humans
- Hypertension, Pulmonary
(complications)
- Male
- Pulmonary Artery
- Retrospective Studies
- Risk Factors
- Ventricular Dysfunction, Right
(etiology)
- Ventricular Remodeling
|