The circulating concentration of N-terminal pro-
brain natriuretic peptide (
NT-proBNP) has been shown to be a diagnostic tool for the detection of
heart failure. Several factors influence
NT-proBNP levels including age, sex, and body mass index (BMI). Therefore, the diagnostic sensitivity of
NT-proBNP level for
heart failure is relatively higher, but its specificity is low. This study aims to improve the diagnostic accuracy rate of this test by including multiple variables in the diagnostic test.The suspected chronic
heart failure outpatients were divided into
heart failure with reduced ejection fraction,
heart failure with mid-range ejection fraction,
heart failure with preserved ejection fraction, and normal heart function groups. Area under the receiver-operating characteristic (ROC) curve, cut-off value, and logistic regression analysis were used to select the model variables, sensitivity and specificity.In all, 436 subjects enrolled into this study were divided in 2 groups: model establishment (n = 300) and model validation (n = 136). In the model establishment group, the area under the curve (AUC) and cut-off value of
NT-proBNP was 0.926 and 257.4 pg/mL, respectively. When age, glomerular filtration rate, BMI,
atrial fibrillation, and sex were entered into the diagnosis model, AUC, sensitivity, and specificity further increased to 0.955 (95% confidence interval [CI] 0.934, 0.976), 94.2% (from 93.0%), and 86.7% (from 74.2%). The ROC curve of corrected
NT-proBNP diagnostic formula for
heart failure was also significantly higher (P = .037).The corrected
NT-proBNP diagnostic formula was found to improve the diagnostic accuracy of chronic
heart failure.