Pharmacokinetics of cefquinome in healthy and Pasteurella multocida-infected rabbits.

Abstract

The pharmacokinetics of cefquinome were studied in healthy and Pasteurella multocida-infected rabbits after a single intramuscular (IM) injection at 2 mg/kg of its sulfate salt. Twelve female New Zealand white rabbits (2.0-2.5 kg) were used; six of them served as controls, and the other six had been infected with P. multocida; the experiments were conducted 1-2 days after nasal inoculation of P. multocida when rabbits showed the signs of respiratory infection. Plasma concentrations of cefquinome were determined using high-performance liquid chromatography. The values of elimination half-life, area under the curve, area under the first moment curve, and mean residence time were significantly lower in infected rabbits (0.48 hr, 4.54 hr*μg/ml, 3.63 hr* hr*μg/ml and 0.8 hr, respectively) than healthy rabbits (0.72 hr, 9.11 hr*μg/ml, 9.85 hr* hr*μg/ml and 1.1 hr, respectively), whereas total body clearance was significantly higher in infected than healthy rabbits. Therefore, P. multocida infection caused significant changes in some of the pharmacokinetic parameters of cefquinome in rabbits. These pharmacokinetic changes may affect dose regimen when used in P. multocida-infected rabbits.

• Authors: S T Elazab, D E Schrunk, R W Griffith, S M Ensley, G Dell'Anna, K Mullin, M G Elsayed, M S Amer, S M El-Nabtity, W H Hsu
• Journal: Journal of veterinary pharmacology and therapeutics (J Vet Pharmacol Ther) Vol. 41 Issue 3 Pg. 374-377 (Jun 2018) ISSN: 1365-2885 [Electronic] England
• PMID: 29383736 (Publication Type: Controlled Clinical Trial, Journal Article)
• Copyright: © 2018 John Wiley & Sons Ltd.

Chemical References

• Cephalosporins
• cefquinome

Topics

• Animals
• Area Under Curve
• Cephalosporins (pharmacokinetics, therapeutic use)
• Female
• Half-Life
• Pasteurella Infections (drug therapy, microbiology, veterinary)
• Pasteurella multocida
• Rabbits