Generation of the Maternal Low-Protein Rat Model for Studies of Metabolic Disorders.

Abstract

Poor nutrition during pregnancy leads to an increased risk of metabolic disorders and other diseases in the offspring. This can be modelled in animals through manipulation of the maternal diet. One such model is the maternal low-protein rat which gives rise to offspring characterized by insulin resistance. This chapter gives a detailed protocol for generation of the maternal low-protein rat, which has been used in the study of several disorders including diabetes and psychiatric disorders.

• Authors: Dan Ma, Susan E Ozanne, Paul C Guest
• Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 1735 Pg. 201-206 ( 2018) ISSN: 1940-6029 [Electronic] United States
• PMID: 29380313 (Publication Type: Journal Article)

Chemical References

• Dietary Proteins

Topics

• Animals
• Dietary Proteins (administration & dosage, metabolism)
• Disease Models, Animal
• Female
• Maternal Exposure
• Metabolic Diseases (etiology, metabolism)
• Pregnancy
• Prenatal Exposure Delayed Effects
• Protein Deficiency (complications)
• Rats