Venipuncture
pain is an uncomfortable suffering to the patient. It creates anxiety, fear and dissatisfaction. The
ketoprofen transdermal patch is a proven treatment for musculoskeletal and arthritic
pain. We planned this study to evaluate the efficacy of the
ketoprofen patch to reduce venipuncture
pain.
METHODS: Two hundred adult patients, aged 18-60 years, of either sex, ASA grade I or II, were enrolled. Presuming that
therapy would decrease venipuncture
pain by 30%, a power calculation with α = 0.05 and β = 0.80 required enrollment of at least 24 patients into each group. However, 100 patients in each group were recruited. Group I (Control) received a placebo patch; Group II (
Ketoprofen) received a 20 mg
ketoprofen patch. A selected vein on the dorsum of the patient's non-dominant hand was cannulated with 18 g intravenous
cannula 1 h after the application of the respective patch. Assessment of
pain was done by
a 10 cm visual analogue scale (VAS) of 0-10, where 0 depicts "no
pain" and 10 is "the worst imaginable
pain". The venipuncture site was assessed for the presence of skin
erythema, swelling and rashes at 12 h, 24 h and at the time of decannulation.
RESULTS: Incidence of
pain was 100% (94/94) in the control group as compared to 93% (85/91) in the
ketoprofen group. The severity of the venipuncture
pain was 6 (2) and 2 (2) for control and
ketoprofen groups respectively (P < 0.05).
CONCLUSIONS: