PIK3R3 promotes chemotherapeutic sensitivity of colorectal cancer through PIK3R3/NF-kB/TP pathway.

Abstract	Phosphoinositide-3-kinase regulatory subunit 3(PIK3R3) is overexpressed in different types of human cancer. We previously reported the important role of PIK3R3 in colorectal cancer (CRC). However, the prognosis effect of PIK3R3 in CRC is still remaining unclear. In this study, we explored online clinical databases to analyze the prognosis differences between higher and lower expression of PIK3R3 in CRC patients. Interestingly, we found that better disease-free survival (DFS) were occurred in patients with higher expression of PIK3R3, but there is no significant difference in overall survival (OS). For further, we showed that PIK3R3 could enhance 5-FU induced apoptosis by regulating the expression of thymmidine phosphorylase (TP). In conclusion, PIK3R3 could be considered as a predictor of 5-FU sensitivity for personalized treatment, and a therapeutic target for colorectal cancer.
Authors	Sidikjan Ibrahim, Guodong Li, Fuqing Hu, Zhenlin Hou, Qianzhi Chen, Geng Li, Xuelai Luo, Junbo Hu, Yongdong Feng
Journal	Cancer biology & therapy (Cancer Biol Ther) Vol. 19 Issue 3 Pg. 222-229 (03 04 2018) ISSN: 1555-8576 [Electronic] United States
PMID	29370570 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antimetabolites, Antineoplastic NF-kappa B Thymidine Phosphorylase Phosphatidylinositol 3-Kinases PIK3R3 protein, human Fluorouracil
Topics	Animals Antimetabolites, Antineoplastic (pharmacology, therapeutic use) Apoptosis (drug effects) Colorectal Neoplasms (drug therapy, mortality, pathology, surgery) Datasets as Topic Disease-Free Survival Drug Resistance, Neoplasm Female Fluorouracil (pharmacology, therapeutic use) HT29 Cells Humans Kaplan-Meier Estimate Mice Mice, Nude NF-kappa B (metabolism) Phosphatidylinositol 3-Kinases (metabolism) Prognosis Thymidine Phosphorylase (metabolism) Xenograft Model Antitumor Assays

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