Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial.

Abstract

Diabetic dyslipidemia with elevated postprandial triglyceride (TG) responses is characteristic in type 2 diabetes (T2D). Diet and meal timing can modify postprandial lipemia (PPL). The impact of a pre-meal of whey proteins (WP) on lipid metabolism is unidentified. We determined whether a WP pre-meal prior to a fat-rich meal influences TG and apolipoprotein B-48 (ApoB-48) responses differentially in patients with and without T2D. Two matched groups of 12 subjects with and without T2D accomplished an acute, randomized, cross-over trial. A pre-meal of WP (20 g) or water (control) was consumed 15 min before a fat-rich meal (supplemented with 20 g WP in case of water pre-meal). Postprandial responses were examined during a 360-min period. A WP pre-meal significantly increased postprandial concentrations of insulin (P < 0.0001), glucagon (P < 0.0001) and glucose-dependent insulinotropic peptide (GIP) (P < 0.0001) in subjects with and without T2D. We detected no effects of the WP pre-meal on TG, ApoB-48, or non-esterified fatty acids (NEFA) responses to the fat-rich meal in either group. Paracetamol absorption i.e. gastric emptying was delayed by the WP pre-meal (P = 0.039). In conclusion, the WP pre-meal induced similar hormone and lipid responses in subjects with and without T2D. Thus, the WP pre-meal enhanced insulin, glucagon and GIP responses but did not influence lipid or glucose responses. In addition, we demonstrated that a WP pre-meal reduced gastric emptying in both groups.

• Authors: Ann Bjørnshave, Jens Juul Holst, Kjeld Hermansen
• Journal: Nutrients (Nutrients) Vol. 10 Issue 2 (Jan 25 2018) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 29370144 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Apolipoprotein B-48
• Blood Glucose
• Fatty Acids, Nonesterified
• Glycated Hemoglobin A
• Insulin
• Triglycerides
• Whey Proteins
• Acetaminophen
• Gastric Inhibitory Polypeptide
• Glucagon-Like Peptide 1
• Glucagon

Topics

• Acetaminophen (pharmacokinetics)
• Aged
• Apolipoprotein B-48 (blood)
• Blood Glucose (metabolism)
• Cross-Over Studies
• Diabetes Mellitus, Type 2 (metabolism)
• Diet
• Fatty Acids, Nonesterified (blood)
• Female
• Gastric Emptying
• Gastric Inhibitory Polypeptide (blood)
• Glucagon (blood)
• Glucagon-Like Peptide 1 (blood)
• Glycated Hemoglobin (metabolism)
• Humans
• Insulin (blood)
• Male
• Meals
• Middle Aged
• Postprandial Period
• Triglycerides (blood)
• Whey Proteins (administration & dosage)