Acupuncture inhibition of methamphetamine-induced behaviors, dopamine release and hyperthermia in the nucleus accumbens: mediation of group II mGluR.

Abstract

Methamphetamine (METH) increases metabolic neuronal activity in the mesolimbic dopamine (DA) system and mediates the reinforcing effect. To explore the underlying mechanism of acupuncture intervention in reducing METH-induced behaviors, we investigated the effect of acupuncture on locomotor activity, ultrasonic vocalizations, extracellular DA release in the nucleus accumbens (NAcs) using fast-scan cyclic voltammetry and alterations of brain temperature (an indicator of local brain metabolic activity) produced by METH administration. When acupuncture was applied to HT7, but not TE4, both locomotor activity and 50-kHz ultrasonic vocalizations were suppressed in METH-treated rats. Acupuncture at HT7 attenuated the enhancement of electrically stimulated DA release in the NAc of METH-treated rats. Systemic injection of METH produced a sustained increase in NAc temperature, which was reversed by the DA D1 receptor antagonist SCH 23390 or acupuncture at HT7. Acupuncture inhibition of METH-induced NAc temperature was prevented by pre-treatment with a group II metabotropic glutamate receptors (mGluR2/3) antagonist EGLU into the NAc or mimicked by injection of an mGluR2/3 agonist DCG-IV into the NAc. These results suggest that acupuncture reduces extracellular DA release and metabolic neuronal activity in the NAc through activation of mGluR2/3 and suppresses METH-induced affective states and locomotor behavior.

• Authors: Nam Jun Kim, Yeonhee Ryu, Bong Hyo Lee, Suchan Chang, Yu Fan, Young S Gwak, Chae Ha Yang, Kyle B Bills, Scott C Steffensen, Jin Suk Koo, Eun Young Jang, Hee Young Kim
• Journal: Addiction biology (Addict Biol) Vol. 24 Issue 2 Pg. 206-217 (03 2019) ISSN: 1369-1600 [Electronic] United States
• PMID: 29363229 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 Society for the Study of Addiction.

Chemical References

• Central Nervous System Stimulants
• Cyclopropanes
• Excitatory Amino Acid Antagonists
• Glutamates
• Receptors, Metabotropic Glutamate
• metabotropic glutamate receptor 2
• alpha-ethylglutamic acid
• 2-(2,3-dicarboxycyclopropyl)glycine
• Methamphetamine
• Glycine
• Dopamine

Topics

• Acupuncture Therapy
• Animals
• Body Temperature (drug effects)
• Central Nervous System Stimulants (pharmacology)
• Cyclopropanes (pharmacology)
• Dopamine (metabolism)
• Excitatory Amino Acid Antagonists (pharmacology)
• Glutamates (pharmacology)
• Glycine (analogs & derivatives, pharmacology)
• Locomotion (drug effects)
• Male
• Methamphetamine (pharmacology)
• Nucleus Accumbens (drug effects)
• Rats, Sprague-Dawley
• Receptors, Metabotropic Glutamate (antagonists & inhibitors, physiology)
• Vocalization, Animal (drug effects)