Abstract | BACKGROUND: OBJECTIVE: The objective of this study was to summarize clinical and economic outcomes associated with PCN allergy and provide recommendations for future cost-effectiveness analyses for PCN allergy testing. METHODS: A literature search was conducted using SCOPUS, EMBASE, and PubMed, including all articles published any date through April 25, 2017 (PROSPERO Registration number 42017064112). A total of 1518 abstracts were found during the initial search with 96 duplicates, for a total of 1422 articles for screening. Thirty articles were included for qualitative synthesis and full data extraction. RESULTS: The majority of the studies included had an observational design focusing on inpatient admissions. The most frequently measured outcome in the context of PCN allergy was optimizing antibiotic therapy. Patients with PCN allergy were found to have direct drug costs during inpatient admission ranging from no difference to an additional $609/patient compared with patients without PCN allergy. Outpatient prescription costs were estimated from $14 to $193/patient higher for PCN allergic patients. Total inpatient costs were less for patients without PCN allergy with average savings from $1145 to $4254/patient. CONCLUSIONS: Evaluations of clinical and economic outcomes of PCN allergy are primarily observational and focus on inpatient populations. Long-term relationships between PCN allergy and clinical and economic outcomes are unknown.
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Authors | T Joseph Mattingly 2nd, Anne Fulton, Rachel A Lumish, Anne M C Williams, SeJeong Yoon, Melissa Yuen, Emily L Heil |
Journal | The journal of allergy and clinical immunology. In practice
(J Allergy Clin Immunol Pract)
2018 Sep - Oct
Vol. 6
Issue 5
Pg. 1649-1654.e4
ISSN: 2213-2201 [Electronic] United States |
PMID | 29355644
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review)
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Copyright | Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Allergens
- Anti-Bacterial Agents
- Penicillins
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Topics |
- Allergens
(immunology)
- Anti-Bacterial Agents
(immunology, therapeutic use)
- Costs and Cost Analysis
- Drug Hypersensitivity
(economics)
- Humans
- Penicillins
(immunology, therapeutic use)
- Self Report
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