Abstract | BACKGROUND: Treatment for cancer may lead to development of cognitive difficulties in cancer survivors. This study aimed to evaluate long-term cognitive functioning (CogF) in germ-cell tumor (GCT) survivors. SUBJECTS, MATERIALS, AND METHODS: GCT survivors (n = 155) from the National Cancer Institute of Slovakia completed the Functional Assessment of Cancer Therapy Cognitive Function at a median of 10 years of follow-up (range: 5-32). The study group consisted of survivors receiving a cisplatin-based chemotherapy, radiotherapy to the retroperitoneal lymph nodes, or both, whereas the control group included survivors treated with orchiectomy only. RESULTS: CONCLUSION: This prospective study shows that GCT survivors suffer from a long-term CogF impairment. These results may help guide clinicians' decisions in treatment and follow-up of GCTs. IMPLICATIONS FOR PRACTICE:
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Authors | Michal Chovanec, Lucia Vasilkova, Lucia Setteyova, Jana Obertova, Patrik Palacka, Katarina Rejlekova, Zuzana Sycova-Mila, Katarina Kalavska, Daniela Svetlovska, Silvia Cingelova, Beata Mladosievicova, Jozef Mardiak, Michal Mego |
Journal | The oncologist
(Oncologist)
Vol. 23
Issue 5
Pg. 617-623
(05 2018)
ISSN: 1549-490X [Electronic] England |
PMID | 29352051
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © AlphaMed Press 2018. |
Topics |
- Adult
- Aged
- Cancer Survivors
- Cognition
(drug effects)
- Humans
- Male
- Middle Aged
- Neoplasms, Germ Cell and Embryonal
(mortality, pathology, psychology)
- Prospective Studies
- Testicular Neoplasms
(mortality, pathology, psychology)
- Young Adult
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