Abstract |
Equine serum hepatitis (i.e., Theiler's disease) is a serious and often life-threatening disease of unknown etiology that affects horses. A horse in Nebraska, USA, with serum hepatitis died 65 days after treatment with equine-origin tetanus antitoxin. We identified an unknown parvovirus in serum and liver of the dead horse and in the administered antitoxin. The equine parvovirus- hepatitis (EqPV-H) shares <50% protein identity with its phylogenetic relatives of the genus Copiparvovirus. Next, we experimentally infected 2 horses using a tetanus antitoxin contaminated with EqPV-H. Viremia developed, the horses seroconverted, and acute hepatitis developed that was confirmed by clinical, biochemical, and histopathologic testing. We also determined that EqPV-H is an endemic infection because, in a cohort of 100 clinically normal adult horses, 13 were viremic and 15 were seropositive. We identified a new virus associated with equine serum hepatitis and confirmed its pathogenicity and transmissibility through contaminated biological products.
|
Authors | Thomas J Divers, Bud C Tennant, Arvind Kumar, Sean McDonough, John Cullen, Nishit Bhuva, Komal Jain, Lokendra Singh Chauhan, Troels Kasper Høyer Scheel, W Ian Lipkin, Melissa Laverack, Sheetal Trivedi, Satyapramod Srinivasa, Laurie Beard, Charles M Rice, Peter D Burbelo, Randall W Renshaw, Edward Dubovi, Amit Kapoor |
Journal | Emerging infectious diseases
(Emerg Infect Dis)
Vol. 24
Issue 2
Pg. 303-310
(02 2018)
ISSN: 1080-6059 [Electronic] United States |
PMID | 29350162
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
|
Topics |
- Animals
- Cardiovirus Infections
(veterinary, virology)
- Drug Contamination
- Female
- Hepatitis, Viral, Animal
(virology)
- Horse Diseases
(virology)
- Horses
- Parvoviridae Infections
(veterinary, virology)
- Parvovirinae
(genetics, isolation & purification)
- Phylogeny
- Tetanus Antitoxin
(adverse effects)
- Vaccination
(adverse effects)
- Viremia
|