Efficacy of Continuous Interleukin 1 Blockade in Mevalonate Kinase Deficiency: A Multicenter Retrospective Study in 13 Adult Patients and Literature Review.

Abstract

OBJECTIVE:

To report efficacy and tolerance of interleukin 1 blockade in adult patients with mevalonate kinase deficiency (MKD).

METHODS:

We retrospectively collected data on 13 patients with MKD who had received anakinra (n = 10) and canakinumab (n = 7).

RESULTS:

Anakinra resulted in complete or partial remission in 3/10 and 5/10 patients, respectively, and no efficacy in 2/10, but a switch to canakinumab led to partial remission. Canakinumab resulted in complete or partial remission in 3/7 and 4/7 patients, respectively.

CONCLUSION:

These data support frequent partial responses, showing a better response with canakinumab. The genotype and therapeutic outcomes correlation should help in the personalization of treatment.

• Authors: Samuel Deshayes, Sophie Georgin-Lavialle, Arnaud Hot, Cécile-Audrey Durel, Eric Hachulla, Nicolas Rouanes, Sylvain Audia, Thomas Le Gallou, Pierre Quartier, Geoffrey Urbanski, Laurent Messer, Stéphane Klein, Hubert de Boysson, Boris Bienvenu, Gilles Grateau, Achille Aouba
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 45 Issue 3 Pg. 425-429 (03 2018) ISSN: 0315-162X [Print] Canada
• PMID: 29335349 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Antirheumatic Agents
• IL1B protein, human
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-1beta
• canakinumab

Topics

• Adolescent
• Adult
• Antibodies, Monoclonal (pharmacology, therapeutic use)
• Antibodies, Monoclonal, Humanized
• Antirheumatic Agents (pharmacology, therapeutic use)
• Chemical and Drug Induced Liver Injury
• Child
• Child, Preschool
• Drug Tolerance
• Female
• France
• Humans
• Infections (chemically induced)
• Injection Site Reaction (etiology)
• Interleukin 1 Receptor Antagonist Protein (adverse effects, pharmacology, therapeutic use)
• Interleukin-1beta (antagonists & inhibitors)
• Male
• Mevalonate Kinase Deficiency (drug therapy)
• Precision Medicine
• Remission Induction
• Retrospective Studies
• Treatment Outcome
• Weight Gain (drug effects)