Objective: To survey the mothers' acceptance of the HPV vaccination for their adolescent girls in Xiamen and to explore the influencing factors. Methods: Mothers of adolescent girls were selected by multistage cluster random sampling. Data of demography of the mothers and girls, the knowledge and attitude of
cervical cancer and
HPV vaccine of the mothers were collected. The influencing factors of mothers' attitudes were analyzed with univariate and multivariate logistic regression. Results: A total of 2 307 mothers were selected. The average age of mothers was (38.0±4.7) years. 13.1% (300) of the mothers had a family history of malignant
tumor. The mothers' acceptance for vaccinating girls was 61.9% (1 428). The awareness rates of HPV and
HPV vaccine were 42.5% (980) and 21.4% (493), respectively. Mothers who had family history of
cancer (OR=1.36, 95%CI:1.02-1.82) showed a greater willingness to vaccinate their girls than the mothers who had not. Mothers who had knowledge of HPV (OR=1.32, 95%CI:1.08-1.62) and HPV (OR=2.03, 95%CI:1.56-2.66)
vaccines showed a greater willingness to vaccinate their girls than the mothers who had not. Conclusion: The mothers' acceptance to vaccinate adolescent girls against
cervical cancer needs to be raised, especially for the mothers who had not family history of
cancer, no-knowledge of HPV and
HPV vaccines.