Management of psoriasis in patients with inflammatory bowel disease: From the Medical Board of the National Psoriasis Foundation.

Abstract

BACKGROUND:

There is a significant association between psoriasis and inflammatory bowel disease (IBD). Many treatments for psoriasis and psoriatic arthritis are also used for IBD.

OBJECTIVE:

To assess therapeutic options for patients with psoriasis and concurrent IBD.

METHODS:

A systematic literature search was performed for clinical studies of biologic and systemic psoriasis medications in psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease, for the period from January 1, 1947, to February 14, 2017. Randomized, controlled, double-blinded studies were selected if available. If not, the next highest level of available evidence was selected.

RESULTS:

Of the 2282 articles identified, 132 were selected. Infliximab and adalimumab have demonstrated efficacy in psoriasis, psoriatic arthritis, ulcerative; colitis, and Crohn's disease. Ustekinumab has demonstrated efficacy in psoriasis, psoriatic arthritis, and Crohn's disease. Certolizumab has demonstrated efficacy in psoriatic arthritis and Crohn's disease. Etanercept, secukinumab, brodalumab, and ixekizumab have demonstrated efficacy in psoriasis and psoriatic arthritis but may exacerbate or induce IBD. Guselkumab has demonstrated efficacy in psoriasis.

LIMITATIONS:

There are no known clinical trials of treatment specifically for concurrent psoriasis and IBD.

CONCLUSIONS:

Infliximab and adalimumab have demonstrated efficacy in psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease; other agents have demonstrated efficacy for some, but not all, of these indications.

• Authors: Scott M Whitlock, Clinton W Enos, April W Armstrong, Alice Gottlieb, Richard G Langley, Mark Lebwohl, Joseph F Merola, Caitriona Ryan, Michael P Siegel, Jeffrey M Weinberg, Jashin J Wu, Abby S Van Voorhees
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 78 Issue 2 Pg. 383-394 (02 2018) ISSN: 1097-6787 [Electronic] United States
• PMID: 29332708 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Dermatologic Agents
• Gastrointestinal Agents
• guselkumab
• Thalidomide
• brodalumab
• Cyclosporine
• golimumab
• Infliximab
• ixekizumab
• secukinumab
• Ustekinumab
• Adalimumab
• Acitretin
• Etanercept
• Certolizumab Pegol
• apremilast

Topics

• Acitretin (therapeutic use)
• Adalimumab (therapeutic use)
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Certolizumab Pegol (therapeutic use)
• Cyclosporine (therapeutic use)
• Dermatologic Agents (therapeutic use)
• Etanercept (therapeutic use)
• Gastrointestinal Agents (therapeutic use)
• Humans
• Inflammatory Bowel Diseases (complications, drug therapy)
• Infliximab (therapeutic use)
• Psoriasis (complications, therapy)
• Thalidomide (analogs & derivatives, therapeutic use)
• Ustekinumab (therapeutic use)