Spontaneous splenic rupture as a rare complication of G-CSF injection.

Abstract

Splenic rupture is an infrequent and underdiagnosed side effect of granylocyte colony-stimulating factor (G-CSF). We report the case of a 54-year-old woman with brain and bone metastasis in a lung adenocarcinoma who was admitted for faintness 28 days after a G-CSF injection. Abdominal CT scan confirmed the diagnosis of splenic rupture. A conservative treatment was chosen using a peritoneal cleansing during laparoscopic surgery. Clinicians should be aware of this rare toxicity as it could be severe, but easily reversible using appropriate surgical treatment. Even if prognosis remains poor for patients with lung cancer, invasive procedures could be considered in this rapidly evolving setting, especially in case of reversible adverse event.

• Authors: Soraya Benguerfi, Fanny Thepault, Hervé Lena, Charles Ricordel
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2018 (Jan 12 2018) ISSN: 1757-790X [Electronic] England
• PMID: 29330272 (Publication Type: Case Reports, Journal Article)
• Copyright: © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Chemical References

• Granulocyte Colony-Stimulating Factor

Topics

• Adenocarcinoma (drug therapy, pathology)
• Adenocarcinoma of Lung
• Antineoplastic Combined Chemotherapy Protocols
• Bone Neoplasms (drug therapy, secondary)
• Brain Neoplasms (drug therapy, secondary)
• Female
• Granulocyte Colony-Stimulating Factor (administration & dosage, adverse effects)
• Humans
• Injections (adverse effects)
• Laparoscopy
• Lung Neoplasms (drug therapy, pathology)
• Middle Aged
• Peritoneal Dialysis (methods)
• Rupture, Spontaneous (etiology, physiopathology, therapy)
• Splenic Rupture (diagnostic imaging, etiology)
• Syncope
• Treatment Outcome