Abstract | BACKGROUND: Cross-sensitivity of rash has been reported between various antiepileptic drugs (AEDs). However, few studies have determined the frequency and management of cross-sensitivity in patients with super-refractory status epilepticus (SRSE). AIMS OF THE STUDY: To examine the optimal AED for treating SRSE with cross-sensitivity. METHODS: We performed a retrospective review of adult patients with SRSE treated at Nagoya City University Hospital, in which we investigated the frequency of cross-sensitivity among patients with SRSE and their clinical and medical profiles. RESULTS: We identified 10 adult patients with SRSE, 5 of whom had cross-sensitivity. Stiripentol (STP) was administered when previously used AEDs had demonstrated cross-sensitivity and failed to control seizures. After initiation of STP, the dose of general anaesthetics was reduced, and status epilepticus (SE) eventually ceased with co-administered AEDs without additional adverse effects. The mean time to SE cessation after initiation of STP was 30.8 days (range, 18-46 days), mean duration of general anaesthesia was 101.2 days (range, 74-128 days), and mean number of AEDs was 9.0 (range, 6-11). CONCLUSIONS: This study suggests that cross-sensitivity between AEDs is common in adults with SRSE and that STP may be useful for treating SRSE with cross-sensitivity.
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Authors | Y Uchida, K Terada, Y Madokoro, T Fujioka, M Mizuno, T Toyoda, D Kato, N Matsukawa |
Journal | Acta neurologica Scandinavica
(Acta Neurol Scand)
Vol. 137
Issue 4
Pg. 432-437
(Apr 2018)
ISSN: 1600-0404 [Electronic] Denmark |
PMID | 29313881
(Publication Type: Journal Article)
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Copyright | © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Anticonvulsants
- Dioxolanes
- stiripentol
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Topics |
- Adult
- Aged
- Anticonvulsants
(adverse effects)
- Dioxolanes
(therapeutic use)
- Drug Eruptions
(etiology)
- Female
- Humans
- Male
- Middle Aged
- Retrospective Studies
- Seizures
(drug therapy)
- Status Epilepticus
(drug therapy)
- Young Adult
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