Abstract | PURPOSE: PATIENTS AND METHODS: F-FDG PET/CT and DCE-MRI studies carried out as part of the South West Area Mesothelioma Pemetrexed trial were used. F-FDG PET/CT and DCE-MRI studies were carried out before treatment, and after two cycles of chemotherapy, on patients treated with pemetrexed and cisplatin. A total of 73 patients were recruited, of whom 65 had PET/CT and DCE-MRI scans. Baseline measurements from F-FDG PET/CT (maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis) and DCE-MRI (integrated area under the first 90s of the curve and washout slope) were compared with overall survival (OS) using Kaplan-Meier and Cox regression analyses, and changes in imaging measurements were compared with disease progression. RESULTS: PET/CT and DCE-MRI measurements were not correlated with each other. Maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis were significantly related to OS with Cox regression analysis and Kaplan-Meir analysis, and DCE-MRI washout curve shape was significantly related to OS. DCE-MRI curve shape can be combined with F-FDG PET/CT to give additional prognostic information. Changes in measurements were not related to progression-free survival. CONCLUSIONS:
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Authors | David O Hall, Clare E Hooper, Julie Searle, Michael Darby, Paul White, John E Harvey, Jeremy P Braybrooke, Nick A Maskell, Vidan Masani, Iain D Lyburn |
Journal | Nuclear medicine communications
(Nucl Med Commun)
Vol. 39
Issue 2
Pg. 161-170
(Feb 2018)
ISSN: 1473-5628 [Electronic] England |
PMID | 29300270
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Contrast Media
- Fluorodeoxyglucose F18
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Topics |
- Aged
- Aged, 80 and over
- Contrast Media
- Disease Progression
- Female
- Fluorodeoxyglucose F18
- Humans
- Image Processing, Computer-Assisted
- Lung Neoplasms
(diagnostic imaging, drug therapy, pathology)
- Magnetic Resonance Imaging
- Male
- Mesothelioma
(diagnostic imaging, drug therapy, pathology)
- Mesothelioma, Malignant
- Positron Emission Tomography Computed Tomography
- Survival Analysis
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