Deer Bone Extract Supplementation for Mild-to-Moderate Knee Osteoarthritis Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial.

Abstract

In this randomized, double-blind, placebo-controlled study, we evaluated the efficacy of deer bone extract (DBE) in participants with knee osteoarthritis (OA). We enrolled 50 participants aged 50-70 years, having knee OA with a Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score ≥5.0. The participants were assigned to the placebo or DBE group (550 mg/day) for 12 weeks. The outcome measures were as follows: pain score on the visual analog scale (VAS); WOMAC score; and blood and urine biomarkers. In the DBE group, VAS scores, WOMAC total scores, and WOMAC subscores (for pain, stiffness, and physical function) improved significantly compared with the baseline values. However, there was no significant difference in outcomes between the DBE and placebo groups. The present findings suggest that DBE may mildly reduce joint pain and stiffness and improve joint function in patients with painful knee OA.

• Authors: Dongseok Shin, Eun Ae Kim, Yoon Young Kim, Min Seo Kim, Jong Hoon Kim, Chang Won Ahn, Soo-Hyun Park, Ki Won Lee, Jae Hwa Kim, Ji Yeon Kim
• Journal: Journal of medicinal food (J Med Food) Vol. 21 Issue 2 Pg. 159-166 (Feb 2018) ISSN: 1557-7600 [Electronic] United States
• PMID: 29298102 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Gangliosides

Topics

• Aged
• Animals
• Arthralgia (drug therapy, pathology, physiopathology)
• Bone and Bones (chemistry)
• Deer
• Double-Blind Method
• Female
• Gangliosides (administration & dosage, analysis)
• Humans
• Knee Joint (drug effects, physiopathology)
• Male
• Middle Aged
• Osteoarthritis, Knee (drug therapy, physiopathology)
• Treatment Outcome