Near infrared (NIR) imaging-guided
photodynamic therapy (
PDT) is remarkable for its high-efficiency in "see and treat" field. However,
hypoxia of
cancer cell limits
PDT dues to the low
singlet oxygen yield. Here MnO2 conjugated multifunctional
polypeptide nanoparticles encapsulating
photosensitizer BODIPY has been prepared via a one-step reaction, which can generate
oxygen in
cancer cytoplasm where rich of H2O2, following
singlet oxygen by
photosensitizer under NIR light irradiation. In vitro studies on HepG2 and 4T1
cancer cells revealed that the as-prepared nanoparticles obviously increase the cell suppression rate under
hypoxia conditions, even exposed to an extremely low light energy density (25 mW/cm2). Meanwhile, excellent NIR fluorescence property of
BODIPY enabled the nanoparticles to light up the
cancer cells for real-time imaging. These results suggest the promises of biocompatible and biodegradable nanoparticles has potential application on efficient NIR imaging-guided
photodynamic therapy.