Abstract | OBJECTIVE: METHODS: OA burden was quantified on the basis of radiographic features as total joint faces with an osteophyte, joint space narrowing, or in the spine, disc space narrowing. sPIIANP was measured in 1,235 participants from the Genetics of Generalized Osteoarthritis study using a competitive enzyme-linked immunosorbent assay. Separate multivariable linear regression models, adjusted for age, sex, and body mass index and additionally for ipsilateral osteophytes or joint/disc space narrowing, were used to assess the independent association of sPIIANP with osteophytes and with joint/disc space narrowing burden in knees, hips, hands and spine, individually and together. RESULTS: After full adjustment, sPIIANP was significantly associated with a lesser burden of hip joint space narrowing and knee osteophytes. sPIIANP was associated with a lesser burden of hand joint space narrowing but a greater burden of hand osteophytes; these results were only evident upon adjustment for osteoarthritic features in all other joints. There were no associations of sPIIANP and features of spine osteoarthritis. CONCLUSIONS: Higher cartilage collagen synthesis, as reflected in systemic PIIANP concentrations, was associated with lesser burden of osteoarthritic features in lower extremity joints (knees and hips), even accounting for osteoarthritis burden in hands and spine, age, sex and body mass index. These results suggest that pro- anabolic agents may be appropriate for early treatment to prevent severe lower extremity large joint osteoarthritis.
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Authors | Hikmat N Daghestani, Joanne M Jordan, Jordan B Renner, Michael Doherty, A Gerry Wilson, Virginia B Kraus |
Journal | PloS one
(PLoS One)
Vol. 12
Issue 12
Pg. e0190251
( 2017)
ISSN: 1932-6203 [Electronic] United States |
PMID | 29287118
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Calcium-Binding Proteins
- Collagen Type II
- chondrocalcin
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Topics |
- Calcium-Binding Proteins
(blood)
- Collagen Type II
(blood)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Male
- Osteoarthritis
(blood, diagnostic imaging, pathology)
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