Prognostic factors in the early phase of acute encephalopathy.

Abstract

BACKGROUND:

Neurological sequelae occur in 40% of patients with acute encephalopathy (AE). The early prediction of poor outcomes is critical to the initiation of appropriate treatment. The aim of the present study was therefore to elucidate prognostic factors that can be quickly and feasibly evaluated on hospital admission in patients with AE.

METHODS:

We analyzed data from 51 AE patients admitted to Hirakata City Hospital between January 2005 and December 2014. Age at onset, sex, underlying disease, status epilepticus (SE), presence of benzodiazepine-resistant SE (BZD-resistant SE), and basic blood serum parameters on admission were evaluated in relation to each patient's outcome.

RESULTS:

On univariate analysis age at onset, BZD-resistant SE, and serum aspartate aminotransferase (AST), alanine aminotransferase, lactate dehydrogenase, and platelet count varied significantly according to outcome. On multivariate analysis age at onset (≤21 months), presence of BZD-resistant SE, and AST (≥46 IU/L) were identified as independent variables associated with poor outcome.

CONCLUSION:

Age at onset, presence of BZD-resistant SE, and AST are associated with a poor prognosis in AE.

• Authors: Chizu Oba, Mitsuru Kashiwagi, Takuya Tanabe, Shohei Nomura, Motoko Ogino, Takuya Matsuda, Shinya Murata, Michiko Nakamura, Akihiko Shirasu, Keisuke Inoue, Keisuke Okasora, Hiroshi Tamai
• Journal: Pediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 60 Issue 3 Pg. 270-275 (Mar 2018) ISSN: 1442-200X [Electronic] Australia
• PMID: 29280262 (Publication Type: Journal Article)
• Copyright: © 2017 Japan Pediatric Society.

Chemical References

• Anticonvulsants
• Free Radical Scavengers
• Glucocorticoids
• Edaravone
• Antipyrine

Topics

• Acute Febrile Encephalopathy (diagnosis, drug therapy)
• Adolescent
• Anticonvulsants (therapeutic use)
• Antipyrine (analogs & derivatives, therapeutic use)
• Child
• Child, Preschool
• Edaravone
• Female
• Free Radical Scavengers (therapeutic use)
• Glucocorticoids (therapeutic use)
• Humans
• Infant
• Japan
• Male
• Prognosis
• Retrospective Studies