Abstract |
Helicases are molecular motors that play central roles in nucleic acid metabolism. Mutations in genes encoding DNA helicases of the RecQ and iron- sulfur (Fe-S) helicase families are linked to hereditary disorders characterized by chromosomal instabilities, highlighting the importance of these enzymes. Moreover, mono-allelic RecQ and Fe-S helicase mutations are associated with a broad spectrum of cancers. This review will discuss and contrast the specialized molecular functions and biological roles of RecQ and Fe-S helicases in DNA repair, the replication stress response, and the regulation of gene expression, laying a foundation for continued research in these important areas of study.
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Authors | Katrina N Estep, Robert M Brosh Jr |
Journal | Biochemical Society transactions
(Biochem Soc Trans)
Vol. 46
Issue 1
Pg. 77-95
(02 19 2018)
ISSN: 1470-8752 [Electronic] England |
PMID | 29273621
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Copyright | © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. |
Chemical References |
- Iron-Sulfur Proteins
- DNA
- DNA Helicases
- RecQ Helicases
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Topics |
- Chromosome Aberrations
- DNA
(metabolism)
- DNA Helicases
(genetics, metabolism)
- Humans
- Iron-Sulfur Proteins
(genetics, metabolism)
- Mutation
- Neoplasms
(enzymology, genetics, metabolism)
- Protein Binding
- RecQ Helicases
(genetics, metabolism)
- Substrate Specificity
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