Osteogenesis imperfecta (OI) is an
hereditary disease characterized by low bone mass, increased bone fragility, short stature, and skeletal
deformities, few treatment options are currently available.
Neridronate is an amino-
bisphosphonate, licensed in Italy for the treatment of OI and
Paget's disease of bone. A characteristic property of
neridronate is that it can be administered both intravenously and intramuscularly, providing an useful system for administration in homecare.
Neridronate appears to increase Bone Mineral Density (BMD) in adults with OI and reduces
bone resorption by inhibition of osteoclastic activity.
Teriparatide (recombinant 1-34 N terminal sequence of human
parathyroid hormone) is the first anabolic agent approved for the treatment of patients with
osteoporosis and has been reported to increase bone formation by stimulating osteoblast differentiation, osteoblast function, and survival. The results of this study showed a promising role of
teriparatide in the
therapy of OI type I.