Clinical data of 620 patients who received investigation of serum
IgG4 in Peking University People's Hospital from January 1, 2015 to March 31, 2016 were collected retrospectively. According to the difference of the diseases, they were divided into common group of
diseases, autoimmune diseases and
IgG4 related
diseases; pancreatic disease patients were divided into
autoimmune pancreatitis and
pancreatic cancer group; According to different treatment stages of the disease, the patients with
IgG4 related diseases were divided into pretreatment group and post treatment group. And the expressions of the patients'serum
IgG4 levels in different groups were analyzed.
RESULTS: The median serum
IgG4 level in the group of the patients with common diseases was 0.480(0.005, 50.400) g/L, in the group of
autoimmune disease was 0.406 (0.003, 18.700) g/L , in the group of
IgG4 related diseases was 5.200(0.046, 46.000)g/L, which was signi-ficantly higher in the group of
IgG4 related diseases than the other two groups, and there was obvious statistical significance in serum
IgG4 levels between the group of
IgG4 related diseases and the other two groups (P<0.01); There was no obvious difference in serum
IgG4 levels between the common disease group and the
autoimmune disease group, and there was no obvious statistical difference in serum
IgG4 levels between the two groups (P>0.05). In the patients with
IgG4 related diseases, the median serum
IgG4 level in the group of pretreatment patients was 6.540 (1.330, 34.100) g/L, and 3.735 (0.063, 46.000) g/L in the post treatment patients. Serum
IgG4 levels decreased in post treatment group, signi-ficantly lower than in pretreatment, there was obvious statistical difference in serum
IgG4 levels between the two groups (P<0.01). The median serum
IgG4 level in the group of patients with
autoimmune pancreatitis was 3.735 (0.063, 46.000) g/L ,and 0.438 (0.056, 1.130) g/L in the group of patients with
pancreatic cancer,which was significantly higher in the group of patients with
autoimmune pancreatitis than the others, and there was obvious statistical difference in serum
IgG4 levels between the two groups (P<0.01).
CONCLUSION: Serum
IgG4 levels in patients with different diseases were different, and were significantly higher in patients with
autoimmune pancreatitis and
IgG4 related diseases, so serum
IgG4 levels can provide the basis for the differential diagnosis of different diseases; Serum
IgG4 levels in patients with
IgG4 related diseases decrease significantly
after treatment, so it can be used as an important index to evaluate the curative effect of
IgG4 related diseases.