Abstract | OBJECTIVE: To investigate the incidence and common types of abnormal hemoglobin diseases of the couples at childbearing age by using high performance liquid chromatography (HPLC) in Guangzhou city. METHODS: The couple of childbearing age in the Birth defect intervention project and Free pre pregnancy health examination were screened from October 2008 to February 2016 in Guangzhou city. The HPLC was used to detect abnormal hemoglobin; The Gap-PCR and reverse dot blot(RDB) were used to detect thalassemia gene deletions. RESULTS: CONCLUSION: The incidence of abnormal hemoglobin diseases in Guangzhou area has been found to be more high, 8 kinds of abnormal hemoglobin are found by HPLC, the HPLC is an effective way to screen the couples of childbearing age for β thalassemia and hemoglobinopathies.
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Authors | Gui-Lan Chen, Yan-Xia Qu, Fan Jiang, Ying Tang, Fang Tang, Lian-Dong Zuo |
Journal | Zhongguo shi yan xue ye xue za zhi
(Zhongguo Shi Yan Xue Ye Xue Za Zhi)
Vol. 25
Issue 6
Pg. 1768-1771
(Dec 2017)
ISSN: 1009-2137 [Print] China |
PMID | 29262913
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Chromatography, High Pressure Liquid
- Female
- Hemoglobinopathies
- Hemoglobins, Abnormal
- Humans
- Pregnancy
- Thailand
- alpha-Thalassemia
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