Abstract | INTRODUCTION: METHODS: The efficacy and residual activity of a novel IRS mixture of deltamethrin and clothianidin was evaluated against wild pyrethroid resistant An. gambiae sl in experimental huts in Cove, Benin. Two application rates of the mixture were tested and comparison was made with clothianidin and deltamethrin applied alone. To assess the residual efficacy of the treatments on different local wall substrates, the inner walls of the experimental huts were covered with either cement, mud or plywood. RESULTS:
Clothianidin demonstrated a clear delayed expression in mortality of wild pyrethroid resistant An. gambiae sl in the experimental huts which reached its full effect 120 hours after exposure. Overall mortality over the 12-month hut trial was 15% in the control hut and 24-29% in the deltamethrin-treated huts. The mixture of clothianidin 200mg/m2 and deltamethrin 25mg/m2 induced high overall hut mortality rates (87% on mud walls, 82% on cement walls and 61% on wooden walls) largely due to the clothianidin component and high hut exiting rates (67-76%) mostly due to the deltamethrin component. Mortality rates remained >80% for 8-9 months on mud and cement walls. The residual activity trend was confirmed by results from monthly in situ cone bioassays with laboratory susceptible An. gambiae Kisumu strain. CONCLUSION:
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Authors | Corine Ngufor, Augustin Fongnikin, Mark Rowland, Raphael N'Guessan |
Journal | PloS one
(PLoS One)
Vol. 12
Issue 12
Pg. e0189575
( 2017)
ISSN: 1932-6203 [Electronic] United States |
PMID | 29252986
(Publication Type: Journal Article)
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Chemical References |
- Guanidines
- Insecticides
- Neonicotinoids
- Pyrethrins
- Thiazoles
- clothianidin
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Topics |
- Animals
- Anopheles
- Benin
- Culex
- Guanidines
- Housing
- Humans
- Insecticide Resistance
- Insecticides
- Malaria
(prevention & control)
- Mosquito Control
(methods)
- Neonicotinoids
- Pyrethrins
- Thiazoles
- World Health Organization
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