Abstract | INTRODUCTION: METHODS: A case-control study was conducted among 3090 Han farmers (1533 essential hypertension patients and 1557 normotensives). Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and polymerase chain reaction-sequencing. RESULTS: The genotypic and allelic distributions of rs2368564 in essential hypertension and control was significant statistically ( p<0.001). The allelic distribution of rs10900557 showed marginal statistical significance ( p=0.048). There were no significant differences in other genotypic and allelic distributions ( p>0.05). In the haplotypes comprised by the six single-nucleotide polymorphisms, there were differences in the distribution of haplotypes A-T-C-G-C-A, A-T-C-G-C-G, G-C-T-G-T-A and G-C-T-G-T-G in both groups, and their differences reached to significant levels, respectively. After having corrected for false discovery rate, this association still remained significant. CONCLUSIONS: The current study provides evidence for a possible association of renin gene polymorphisms with essential hypertension in a Han population of northern China.
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Authors | Guoping Zhang, Xueyan Li, Keyong Zhang, Jingbo Zhao, Changchun Qiu |
Journal | Journal of the renin-angiotensin-aldosterone system : JRAAS
(J Renin Angiotensin Aldosterone Syst)
2017 Oct-Dec
Vol. 18
Issue 4
Pg. 1470320317744917
ISSN: 1752-8976 [Electronic] England |
PMID | 29233044
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Alleles
- Asian People
(genetics)
- Base Sequence
- Case-Control Studies
- China
- Demography
- Essential Hypertension
(genetics)
- Ethnicity
(genetics)
- Genetic Predisposition to Disease
- Genotyping Techniques
- Haplotypes
(genetics)
- Humans
- Middle Aged
- Polymorphism, Single Nucleotide
(genetics)
- Renin
(genetics)
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