Abstract | OBJECTIVES:
Nalbuphine is as effective as morphine as a perioperative analgesic but has not been compared directly with sufentanil in clinical trials. The aims of this study were to compare the efficacy and safety of nalbuphine with that of sufentanil in patients undergoing colonoscopy and to determine the optimal doses of nalbuphine in this indication. METHODS: Two hundred and forty consecutive eligible patients aged 18-65 years with an American Society of Anesthesiologists classification of I-II and scheduled for colonoscopy were randomly allocated to receive sufentanil 0.1 μg/kg (group S), nalbuphine 0.1 mg/kg (group N1), nalbuphine 0.15 mg/kg (group N2), or nalbuphine 0.2 mg/kg (group N3). Baseline vital signs were recorded before the procedure. The four groups were monitored for propofol sedation using the bispectral index, and pain relief was assessed using the Visual Analog Scale and the modified Behavioral Pain Scale for non-intubated patients. The incidences of respiratory depression during endoscopy, nausea, vomiting, drowsiness, and abdominal distention were recorded in the post anesthesia care unit and in the first and second 24-hour periods after colonoscopy. RESULTS: CONCLUSIONS:
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Authors | Chaoyi Deng, Xiao Wang, Qianmei Zhu, Yanming Kang, Jinlin Yang, Heng Wang |
Journal | PloS one
(PLoS One)
Vol. 12
Issue 12
Pg. e0188901
( 2017)
ISSN: 1932-6203 [Electronic] United States |
PMID | 29232379
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Opioid
- Sufentanil
- Nalbuphine
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Topics |
- Adolescent
- Adult
- Aged
- Analgesics, Opioid
(administration & dosage)
- Colonoscopy
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Nalbuphine
(administration & dosage)
- Prospective Studies
- Sufentanil
(administration & dosage)
- Young Adult
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