Association of HLA-DQB1*03:03 with pityriasis rosea in Chinese patients.

Abstract

BACKGROUND:

The association of human leucocyte antigen (HLA) with a variety of diseases has been described, especially with various autoimmune diseases. However, there are few studies on the association between HLA and pityriasis rosea (PR).

AIM:

To investigate the relevance of HLA II alleles with the development of PR.

METHODS:

Typing for HLA-DRB1, HLA-DQA1 and HLA-DQB1 typing was performed in 55 patients with PR and 90 healthy controls (HCs), using sequence-based typing (SBT) and PCR with sequence-specific primers (PCR-SSP), respectively.

RESULTS:

We found that the frequency of HLA-DQB1*03:03 was significantly higher in the PR compared with the HC group [P = 0.001; relative risk (RR) = 2.24; 95% CI 1.38-3.6], while suggestive evidence for a protective effect of HLA-DQB1*06:06 was observed in the study cohort (P < 0.02; RR = 0.40; 95% CI 0.17-0.90).

CONCLUSIONS:

The HLA-DQB1*03:03 allele may be a susceptible factor in patients with PR. In addition, the association of HLA-DQB1*03:03 with PR suggests participation of immunity in the pathogenesis of PR.

• Authors: L-Y Fu, C-C Xu, X-D Zheng, G Chen, J Zhu, P-G Wang
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 43 Issue 4 Pg. 389-392 (Jun 2018) ISSN: 1365-2230 [Electronic] England
• PMID: 29222811 (Publication Type: Journal Article)
• Copyright: © 2017 British Association of Dermatologists.

Chemical References

• HLA-DQ beta-Chains
• HLA-DQB1 antigen

Topics

• Adolescent
• Adult
• Alleles
• Asian People (genetics)
• Case-Control Studies
• Child
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• HLA-DQ beta-Chains (genetics)
• Humans
• Male
• Middle Aged
• Pityriasis Rosea (genetics)
• Polymerase Chain Reaction
• Young Adult